Combination of chromium and biotin found to benefit individuals with type 2 diabetes

Share This Post

When it comes to blood sugar control, it makes sense to avoiding eating too much in the way of foods that tend to disrupt blood sugar levels. This is particularly true for diabetics whose bodies tend not to handle sugar at all well. However, in addition to eating a ‘carbohydrate-controlled’ diet, it can also help to supplement with certain nutrients that might help the body keep blood sugar levels in check. Two nutrients known to participate in the body processes that control blood sugar levels are biotin (one of the B-group vitamins) and chromium (a trace mineral).

Previous research has found that giving these nutrients in combination helped blood sugar control in diabetics [1]. In this study 600 mcg of chromium (in the form of chromium picolinate) and 2 mg of biotin or placebo were given to a group of individuals with type 2 diabetes. Although the treatment lasted only 4 weeks, the nutrient therapy led to significantly lower blood sugar level overall after study participants consumed a glucose-rich drink. Individuals treated with chromium and biotin saw other benefits too, including a reduction in the levels of unhealthy blood fats called triglycerides.

This study yielded promising results, but was somewhat hampered by its short duration and a relatively small number of subjects (just 43). More recently, 600 mcg of chromium and 2 mg of biotin were used again in a group of type 2 diabetics, this time for longer (90 days) and in a larger group of individuals (447) [2].

The individuals in this study had blood their blood sugar levels assessed in two ways:

1. by measuring fasting blood sugar levels
2. by measuring the levels of a substance known as HbA1c (also known as ‘glycosylated haemoglobin) that gives an
indication of blood sugar control over the previous 3 months or so

In non-diabetic individuals, HBA1c levels are usually around 4-6 per cent. Diabetics are generally considered to be doing well if they can keep their HbA1c levels below about 7 per cent. In this study, all individuals had HBA1c levels of 7 per cent or higher, and were considered to be generally ‘poorly controlled’. All participants in this study were taking oral medication for their diabetes.

The results of this study were:

Treatment with chromium and biotin brought about a significant reduction in HBA1c levels of 0.54 per cent (e.g. someone with an HbA1c of 7.54, on average, would have seen their level drop to 7.00).

In individuals with an HbA1c of 10 per cent or more, HBA1c levels fell by an average of 1.76 per cent).

In the group as a whole, fasting blood sugar levels fell significantly (by an average of about 10 mg/dl or 0.5 mmol/l)

In individuals with an HbA1c of 10 per cent or more, fasting blood sugar levels fell by an average of about 35 mg/dl or 1.75 mmol/l)

These results, especially when taken in the context of previous research, suggest that a combination of chromium and biotin may be of considerable benefit to individuals with type 2 diabetes, particularly those whose blood sugar level is generally poorly controlled.


1. Singer GM, et al. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8(6):636-43

2. Albarracin CA, et al. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev 2008;24(1):41-51

More To Explore

Walking versus running

I recently read an interesting editorial in the Journal of American College of Cardiology about the relative benefits of walking and running [1]. The editorial

We uses cookies to improve your experience.